opulation-based Study on the Risks of Cervical Lesion and an Papillomavirus Infection among Women in Beijing,

ownloade kground: Few population-based studies have investigated premalignant and malignant cervical malities in Beijing. thods: A total of 6,385 randomly selected sexually active women were interviewed and examined. al lesion was diagnosed using cytology and histology. High-risk human papillomavirus (HPV) was ed by the second-generation hybrid capture test and typed by gene chip of DNA from paraffinded tissue. ults: The cervical lesion prevalence diagnosed by histology was 5.8%. High-risk HPVoverall prevalence .9%, 50.5% with cervical lesion and 7.4% without cervical lesion. High-risk HPV DNA load increased ncreasing degree of lesions. HPV 16 was the most common type (26.5%) among women with cervical , followed by HPV 58 (8.8%), HPV 33 (7.8%), and HPV 56 (5.3%). Women under 50 years of age, married , pregnancy and delivery status, couple's sexual behavior, contraceptive history, columnar ectopy, and ial vaginosis or trichomonas vaginitis history were more risk factors for HPV infection. Factors for al lesion were similar, but in comparison with HPV infection, all associations were weakened. Only e-aged women, husband's sexual partners, oral contraceptives, columnar ectopy, and history of monas vaginitis remained associated with cervical lesion. clusion: In Beijing, the prevalence of cervical lesion and high-risk HPV is higher than estimated in us reports. HPV 16, 58, and 33 were the most prevalent types. This is relevant for work related to al cancer vaccination. act: The study was conducted to understand the current status and epidemiologic characteristics Imp of women with cervical lesion and HPV infection in Beijing. Cancer Epidemiol Biomarkers Prev; 19(10); OF1–10. ©2010 AACR.